An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier
Joint Authors
Zou, Quan
Wang, Zhen
Guan, Xinjun
Liu, Bin
Wu, Yunfeng
Lin, Ziyu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Biology is meaningful and important to identify cytokines and investigate their various functions and biochemical mechanisms.
However, several issues remain, including the large scale of benchmark datasets, serious imbalance of data, and discovery of new gene families.
In this paper, we employ the machine learning approach based on a novel ensemble classifier to predict cytokines.
We directly selected amino acids sequences as research objects.
First, we pretreated the benchmark data accurately.
Next, we analyzed the physicochemical properties and distribution of whole amino acids and then extracted a group of 120-dimensional (120D) valid features to represent sequences.
Third, in the view of the serious imbalance in benchmark datasets, we utilized a sampling approach based on the synthetic minority oversampling technique algorithm and K-means clustering undersampling algorithm to rebuild the training set.
Finally, we built a library for dynamic selection and circulating combination based on clustering (LibD3C) and employed the new training set to realize cytokine classification.
Experiments showed that the geometric mean of sensitivity and specificity obtained through our approach is as high as 93.3%, which proves that our approach is effective for identifying cytokines.
American Psychological Association (APA)
Zou, Quan& Wang, Zhen& Guan, Xinjun& Liu, Bin& Wu, Yunfeng& Lin, Ziyu. 2013. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
Modern Language Association (MLA)
Zou, Quan…[et al.]. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
American Medical Association (AMA)
Zou, Quan& Wang, Zhen& Guan, Xinjun& Liu, Bin& Wu, Yunfeng& Lin, Ziyu. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030790