Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response
المؤلفون المشاركون
McElvaney, Noel G.
Al-Alawi, Mazen
Mirkovic, Bojana
Lavelle, Gillian
Logan, P. Mark
Greene, Catherine M.
Chotirmall, S. H.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-21
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain circumstances.
Depending on the underlying state of the human immune system, clinical consequences can ensue ranging from an excessive immune response during allergic bronchopulmonary aspergillosis to the formation of an aspergilloma in the immunocompetent state.
The severest infections occur in those who are immunocompromised where invasive pulmonary aspergillosis results in high mortality rates.
The diagnosis of Aspergillus-associated pulmonary disease is based on clinical, radiological, and immunological testing.
An understanding of the innate and inflammatory consequences of exposure to Aspergillus species is critical in accounting for disease manifestations and preventing sequelae.
The major components of the innate immune system involved in recognition and removal of the fungus include phagocytosis, antimicrobial peptide production, and recognition by pattern recognition receptors.
The cytokine response is also critical facilitating cell-to-cell communication and promoting the initiation, maintenance, and resolution of the host response.
In the following review, we discuss the above areas with a focus on the innate and inflammatory response to airway Aspergillus exposure and how these responses may be modulated for therapeutic benefit.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chotirmall, S. H.& Al-Alawi, Mazen& Mirkovic, Bojana& Lavelle, Gillian& Logan, P. Mark& Greene, Catherine M.…[et al.]. 2013. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chotirmall, S. H.…[et al.]. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chotirmall, S. H.& Al-Alawi, Mazen& Mirkovic, Bojana& Lavelle, Gillian& Logan, P. Mark& Greene, Catherine M.…[et al.]. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر