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Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response
Joint Authors
McElvaney, Noel G.
Al-Alawi, Mazen
Mirkovic, Bojana
Lavelle, Gillian
Logan, P. Mark
Greene, Catherine M.
Chotirmall, S. H.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain circumstances.
Depending on the underlying state of the human immune system, clinical consequences can ensue ranging from an excessive immune response during allergic bronchopulmonary aspergillosis to the formation of an aspergilloma in the immunocompetent state.
The severest infections occur in those who are immunocompromised where invasive pulmonary aspergillosis results in high mortality rates.
The diagnosis of Aspergillus-associated pulmonary disease is based on clinical, radiological, and immunological testing.
An understanding of the innate and inflammatory consequences of exposure to Aspergillus species is critical in accounting for disease manifestations and preventing sequelae.
The major components of the innate immune system involved in recognition and removal of the fungus include phagocytosis, antimicrobial peptide production, and recognition by pattern recognition receptors.
The cytokine response is also critical facilitating cell-to-cell communication and promoting the initiation, maintenance, and resolution of the host response.
In the following review, we discuss the above areas with a focus on the innate and inflammatory response to airway Aspergillus exposure and how these responses may be modulated for therapeutic benefit.
American Psychological Association (APA)
Chotirmall, S. H.& Al-Alawi, Mazen& Mirkovic, Bojana& Lavelle, Gillian& Logan, P. Mark& Greene, Catherine M.…[et al.]. 2013. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
Modern Language Association (MLA)
Chotirmall, S. H.…[et al.]. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
American Medical Association (AMA)
Chotirmall, S. H.& Al-Alawi, Mazen& Mirkovic, Bojana& Lavelle, Gillian& Logan, P. Mark& Greene, Catherine M.…[et al.]. Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030841