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Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response
المؤلفون المشاركون
Castro, J.
Russo, M.
Lino dos Santos Franco, A.
Gomes, E.
Resende, Rodrigo R.
Florsheim, Esther
Albuquerque, Layra Lucy
Tavares de Lima, Wothan
de Franco, Marcelo
Ribeiro, Orlando Garcia
Mirotti, L.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors.
Here we evaluated basal (intrinsic) and allergen-induced (extrinsic) airway responses to MCh.
We used two mouse lines selected to respond maximally (AIRmax) or minimally (AIRmin) to innate inflammatory stimuli.
We found that in basal condition AIRmin mice responded more vigorously to MCh than AIRmax.
Treatment with a specific M2 antagonist increased airway response of AIRmax but not of AIRmin mice.
The expression of M2 receptors in the lung was significantly lower in AIRmin compared to AIRmax animals.
AIRmax mice developed a more intense allergic inflammation than AIRmin, and both allergic mouse lines increased airway responses to MCh.
However, gallamine treatment of allergic groups did not affect the responses to MCh.
Our results confirm that low or dysfunctional M2 receptor activity is associated with increased airway responsiveness to MCh and that this trait was inherited during the selective breeding of AIRmin mice and was acquired by AIRmax mice during allergic lung inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castro, J.& Resende, Rodrigo R.& Mirotti, L.& Florsheim, Esther& Albuquerque, Layra Lucy& Lino dos Santos Franco, A.…[et al.]. 2013. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castro, J.…[et al.]. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castro, J.& Resende, Rodrigo R.& Mirotti, L.& Florsheim, Esther& Albuquerque, Layra Lucy& Lino dos Santos Franco, A.…[et al.]. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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