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Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response
Joint Authors
Castro, J.
Russo, M.
Lino dos Santos Franco, A.
Gomes, E.
Resende, Rodrigo R.
Florsheim, Esther
Albuquerque, Layra Lucy
Tavares de Lima, Wothan
de Franco, Marcelo
Ribeiro, Orlando Garcia
Mirotti, L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors.
Here we evaluated basal (intrinsic) and allergen-induced (extrinsic) airway responses to MCh.
We used two mouse lines selected to respond maximally (AIRmax) or minimally (AIRmin) to innate inflammatory stimuli.
We found that in basal condition AIRmin mice responded more vigorously to MCh than AIRmax.
Treatment with a specific M2 antagonist increased airway response of AIRmax but not of AIRmin mice.
The expression of M2 receptors in the lung was significantly lower in AIRmin compared to AIRmax animals.
AIRmax mice developed a more intense allergic inflammation than AIRmin, and both allergic mouse lines increased airway responses to MCh.
However, gallamine treatment of allergic groups did not affect the responses to MCh.
Our results confirm that low or dysfunctional M2 receptor activity is associated with increased airway responsiveness to MCh and that this trait was inherited during the selective breeding of AIRmin mice and was acquired by AIRmax mice during allergic lung inflammation.
American Psychological Association (APA)
Castro, J.& Resende, Rodrigo R.& Mirotti, L.& Florsheim, Esther& Albuquerque, Layra Lucy& Lino dos Santos Franco, A.…[et al.]. 2013. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
Modern Language Association (MLA)
Castro, J.…[et al.]. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
American Medical Association (AMA)
Castro, J.& Resende, Rodrigo R.& Mirotti, L.& Florsheim, Esther& Albuquerque, Layra Lucy& Lino dos Santos Franco, A.…[et al.]. Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030938