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Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow
المؤلفون المشاركون
Mierzejewska, Kasia
Ratajczak, Janina
Kucia, Magda
Klyachkin, Yuri M.
Ratajczak, Mariusz Z.
Abdel-Latif, Ahmed
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-01
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM).
Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs.
To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ).
We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization.
However, if mice were exposed to PHZ together with the CXCR4 blocking agent, AMD3100, a robust synergistic increase in the number of mobilized HSPCs occurred.
We conclude that hemolysis, even if it significantly elevates the S1P level in PB, also requires attenuation of the CXCR4-SDF-1 axis-mediated retention in BM niches for HSPC mobilization to occur.
Our data also further confirm that S1P is a major chemottractant present in plasma and chemoattracts HSPCs into PB under steady-state conditions.
However, to egress from BM, HSPCs first have to be released from BM niches by blocking the SDF-1-CXCR4 retention signal.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mierzejewska, Kasia& Klyachkin, Yuri M.& Ratajczak, Janina& Abdel-Latif, Ahmed& Kucia, Magda& Ratajczak, Mariusz Z.. 2013. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mierzejewska, Kasia…[et al.]. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mierzejewska, Kasia& Klyachkin, Yuri M.& Ratajczak, Janina& Abdel-Latif, Ahmed& Kucia, Magda& Ratajczak, Mariusz Z.. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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