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Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow
Joint Authors
Mierzejewska, Kasia
Ratajczak, Janina
Kucia, Magda
Klyachkin, Yuri M.
Ratajczak, Mariusz Z.
Abdel-Latif, Ahmed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM).
Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs.
To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ).
We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization.
However, if mice were exposed to PHZ together with the CXCR4 blocking agent, AMD3100, a robust synergistic increase in the number of mobilized HSPCs occurred.
We conclude that hemolysis, even if it significantly elevates the S1P level in PB, also requires attenuation of the CXCR4-SDF-1 axis-mediated retention in BM niches for HSPC mobilization to occur.
Our data also further confirm that S1P is a major chemottractant present in plasma and chemoattracts HSPCs into PB under steady-state conditions.
However, to egress from BM, HSPCs first have to be released from BM niches by blocking the SDF-1-CXCR4 retention signal.
American Psychological Association (APA)
Mierzejewska, Kasia& Klyachkin, Yuri M.& Ratajczak, Janina& Abdel-Latif, Ahmed& Kucia, Magda& Ratajczak, Mariusz Z.. 2013. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
Modern Language Association (MLA)
Mierzejewska, Kasia…[et al.]. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
American Medical Association (AMA)
Mierzejewska, Kasia& Klyachkin, Yuri M.& Ratajczak, Janina& Abdel-Latif, Ahmed& Kucia, Magda& Ratajczak, Mariusz Z.. Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic StemProgenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030953