Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections
المؤلفون المشاركون
Sautto, Giuseppe
Clementi, Massimo
Gorini, Giacomo
Mancini, Nicasio
Burioni, Roberto
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-22
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks.
Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles.
On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases.
Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminary in vitro and in vivo models of arbovirus-related infections.
Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens.
However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated.
In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sautto, Giuseppe& Mancini, Nicasio& Gorini, Giacomo& Clementi, Massimo& Burioni, Roberto. 2013. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mancini, Nicasio…[et al.]. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sautto, Giuseppe& Mancini, Nicasio& Gorini, Giacomo& Clementi, Massimo& Burioni, Roberto. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر