Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections
Joint Authors
Sautto, Giuseppe
Clementi, Massimo
Gorini, Giacomo
Mancini, Nicasio
Burioni, Roberto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
More than 150 arboviruses belonging to different families are known to infect humans, causing endemic infections as well as epidemic outbreaks.
Effective vaccines to limit the occurrence of some of these infections have been licensed, while for the others several new immunogens are under development mostly for their improvements concerning safety and effectiveness profiles.
On the other hand, specific and effective antiviral drugs are not yet available, posing an urgent medical need in particular for emergency cases.
Neutralizing monoclonal antibodies (mAbs) have been demonstrated to be effective in the treatment of several infectious diseases as well as in preliminary in vitro and in vivo models of arbovirus-related infections.
Given their specific antiviral activity as well-tolerated molecules with limited side effects, mAbs could represent a new therapeutic approach for the development of an effective treatment, as well as useful tools in the study of the host-virus interplay and in the development of more effective immunogens.
However, before their use as candidate therapeutics, possible hurdles (e.g., Ab-dependent enhancement of infection, occurrence of viral escape variants) must be carefully evaluated.
In this review are described the main arboviruses infecting humans and candidate mAbs to be possibly used in a future passive immunotherapy.
American Psychological Association (APA)
Sautto, Giuseppe& Mancini, Nicasio& Gorini, Giacomo& Clementi, Massimo& Burioni, Roberto. 2013. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
Modern Language Association (MLA)
Mancini, Nicasio…[et al.]. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
American Medical Association (AMA)
Sautto, Giuseppe& Mancini, Nicasio& Gorini, Giacomo& Clementi, Massimo& Burioni, Roberto. Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-1030985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030985