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Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice
المؤلفون المشاركون
Nishijo, Hisao
Zhao, Juanjuan
Urakawa, Susumu
Matsumoto, Jumpei
Li, Ruixi
Peng, Yuwen
Ono, Taketoshi
Sasahara, Masakiyo
Ishii, Yoko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-11
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors.
Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR-β) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons.
Although PDGFR-β-knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown.
In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR-β KO mice.
Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR-β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice.
Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice.
These findings suggest that PDGFR-β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Juanjuan& Urakawa, Susumu& Matsumoto, Jumpei& Li, Ruixi& Ishii, Yoko& Sasahara, Masakiyo…[et al.]. 2013. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Juanjuan…[et al.]. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Juanjuan& Urakawa, Susumu& Matsumoto, Jumpei& Li, Ruixi& Ishii, Yoko& Sasahara, Masakiyo…[et al.]. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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