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Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice
Joint Authors
Nishijo, Hisao
Zhao, Juanjuan
Urakawa, Susumu
Matsumoto, Jumpei
Li, Ruixi
Peng, Yuwen
Ono, Taketoshi
Sasahara, Masakiyo
Ishii, Yoko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors.
Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR-β) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons.
Although PDGFR-β-knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown.
In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR-β KO mice.
Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR-β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice.
Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice.
These findings suggest that PDGFR-β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.
American Psychological Association (APA)
Zhao, Juanjuan& Urakawa, Susumu& Matsumoto, Jumpei& Li, Ruixi& Ishii, Yoko& Sasahara, Masakiyo…[et al.]. 2013. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
Modern Language Association (MLA)
Zhao, Juanjuan…[et al.]. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
American Medical Association (AMA)
Zhao, Juanjuan& Urakawa, Susumu& Matsumoto, Jumpei& Li, Ruixi& Ishii, Yoko& Sasahara, Masakiyo…[et al.]. Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031011