Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients
المؤلفون المشاركون
De Pergola, Giovanni
Nitti, Alessandro
Bartolomeo, Nicola
Gesuita, Antonella
Giagulli, Vito Angelo
Triggiani, Vincenzo
Guastamacchia, Edoardo
Silvestris, Francesco
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A cohort of 66 healthy overweight and obese patients, 53 women and 13 men were examined.
Waist circumference and fasting 25(OH)D, insulin, glucose, lipid (cholesterol, HDL cholesterol, and triglyceride), C-reactive protein (CRP), and complement 3 (C3), and 4 (C4) serum concentrations were measured.
Insulin resistance was assessed by the homeostasis model assessment (HOMAIR).
Results.
25(OH)D levels showed a significant negative correlation with BMI (P<0.01), waist circumference (P<0.05), fasting insulin (P<0.01), HOMAIR (P<0.01), triglycerides (P<0.01), CRP (P<0.01), C3 (P<0.05), and C4 (P<0.05).
Multiple regression analyses were performed with 25(OH)D as the dependent variable and BMI (or waist circumferences), fasting insulin (or HOMAIR), triglycerides, and CRP (or C3 or C4) as independent variables.
Only insulin or HOMAIR maintained a significant independent association with 25(OH)D levels, whereas vitamin D did not maintain a significant independent association with CRP or C3 or C4 concentrations.
Conclusions.
The present study, performed in overweight and obese subjects, shows that 25(OH)D levels are negatively associated with inflammatory parameters such as CRP and C3 and C4 levels, but not independently of BMI, body fat distribution, insulin levels, or insulin resistance.
Our results suggest that hyperinsulinemia and/or insulin resistance are directly responsible for decrease of 25(OH)D levels in obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Pergola, Giovanni& Nitti, Alessandro& Bartolomeo, Nicola& Gesuita, Antonella& Giagulli, Vito Angelo& Triggiani, Vincenzo…[et al.]. 2013. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Pergola, Giovanni…[et al.]. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Pergola, Giovanni& Nitti, Alessandro& Bartolomeo, Nicola& Gesuita, Antonella& Giagulli, Vito Angelo& Triggiani, Vincenzo…[et al.]. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر