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Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients
Joint Authors
De Pergola, Giovanni
Nitti, Alessandro
Bartolomeo, Nicola
Gesuita, Antonella
Giagulli, Vito Angelo
Triggiani, Vincenzo
Guastamacchia, Edoardo
Silvestris, Francesco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A cohort of 66 healthy overweight and obese patients, 53 women and 13 men were examined.
Waist circumference and fasting 25(OH)D, insulin, glucose, lipid (cholesterol, HDL cholesterol, and triglyceride), C-reactive protein (CRP), and complement 3 (C3), and 4 (C4) serum concentrations were measured.
Insulin resistance was assessed by the homeostasis model assessment (HOMAIR).
Results.
25(OH)D levels showed a significant negative correlation with BMI (P<0.01), waist circumference (P<0.05), fasting insulin (P<0.01), HOMAIR (P<0.01), triglycerides (P<0.01), CRP (P<0.01), C3 (P<0.05), and C4 (P<0.05).
Multiple regression analyses were performed with 25(OH)D as the dependent variable and BMI (or waist circumferences), fasting insulin (or HOMAIR), triglycerides, and CRP (or C3 or C4) as independent variables.
Only insulin or HOMAIR maintained a significant independent association with 25(OH)D levels, whereas vitamin D did not maintain a significant independent association with CRP or C3 or C4 concentrations.
Conclusions.
The present study, performed in overweight and obese subjects, shows that 25(OH)D levels are negatively associated with inflammatory parameters such as CRP and C3 and C4 levels, but not independently of BMI, body fat distribution, insulin levels, or insulin resistance.
Our results suggest that hyperinsulinemia and/or insulin resistance are directly responsible for decrease of 25(OH)D levels in obesity.
American Psychological Association (APA)
De Pergola, Giovanni& Nitti, Alessandro& Bartolomeo, Nicola& Gesuita, Antonella& Giagulli, Vito Angelo& Triggiani, Vincenzo…[et al.]. 2013. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
Modern Language Association (MLA)
De Pergola, Giovanni…[et al.]. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
American Medical Association (AMA)
De Pergola, Giovanni& Nitti, Alessandro& Bartolomeo, Nicola& Gesuita, Antonella& Giagulli, Vito Angelo& Triggiani, Vincenzo…[et al.]. Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031097