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Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population
المؤلفون المشاركون
Şahın, Server
Rüstemoğlu, Aydın
Tekcan, Akın
Güven, Hasan
Yığıt, Serbülent
Tasliyurt, Turker
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-677، 677ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-06
دولة النشر
مصر
عدد الصفحات
677
التخصصات الرئيسية
الملخص EN
Objective.
Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two.
The leptin (LEP) and leptin receptor (LEPR) genes have been evaluated for polymorphisms that could potentially be related to the pathophysiology of obesity and its complications.
The aim of this study was to investigate the role of LEP G2548A and LEPR 668A/G polymorphisms in the pathogenesis of obesity.
Subjects.
The study included 127 patients with obesity and 105 healthy controls.
Polymerase chain reaction and restriction fragment length analysis for LEP G2548A and LEPR 668A/G polymorphisms were applied.
Results.
There was no statistically significant difference in the genotype frequencies of the LEP gene polymorphism between patients and control groups (P>0.05).
We found a difference in the LEPR genotypes between patients and controls, but this was not statistically significant (P=0.05).
Additionally, we found an increased risk of obesity in the LEP/LEPR GG/GG combined genotype (P<0.05).
Conclusion.
Our findings indicate that the LEP G2548A polymorphism is not a relevant obesity marker and that the LEPR 668A/G polymorphism may be related to obesity in a Turkish population.
Further researches with larger patient population are necessary to ascertain the implications of LEP and LEPR polymorphisms in obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Şahın, Server& Rüstemoğlu, Aydın& Tekcan, Akın& Tasliyurt, Turker& Güven, Hasan& Yığıt, Serbülent. 2013. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers،Vol. 2013, no. 2013, pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Şahın, Server…[et al.]. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers No. 2013 (2013), pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Şahın, Server& Rüstemoğlu, Aydın& Tekcan, Akın& Tasliyurt, Turker& Güven, Hasan& Yığıt, Serbülent. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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