![](/images/graphics-bg.png)
Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population
Joint Authors
Şahın, Server
Rüstemoğlu, Aydın
Tekcan, Akın
Güven, Hasan
Yığıt, Serbülent
Tasliyurt, Turker
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-677, 677 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
677
Main Subjects
Abstract EN
Objective.
Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two.
The leptin (LEP) and leptin receptor (LEPR) genes have been evaluated for polymorphisms that could potentially be related to the pathophysiology of obesity and its complications.
The aim of this study was to investigate the role of LEP G2548A and LEPR 668A/G polymorphisms in the pathogenesis of obesity.
Subjects.
The study included 127 patients with obesity and 105 healthy controls.
Polymerase chain reaction and restriction fragment length analysis for LEP G2548A and LEPR 668A/G polymorphisms were applied.
Results.
There was no statistically significant difference in the genotype frequencies of the LEP gene polymorphism between patients and control groups (P>0.05).
We found a difference in the LEPR genotypes between patients and controls, but this was not statistically significant (P=0.05).
Additionally, we found an increased risk of obesity in the LEP/LEPR GG/GG combined genotype (P<0.05).
Conclusion.
Our findings indicate that the LEP G2548A polymorphism is not a relevant obesity marker and that the LEPR 668A/G polymorphism may be related to obesity in a Turkish population.
Further researches with larger patient population are necessary to ascertain the implications of LEP and LEPR polymorphisms in obesity.
American Psychological Association (APA)
Şahın, Server& Rüstemoğlu, Aydın& Tekcan, Akın& Tasliyurt, Turker& Güven, Hasan& Yığıt, Serbülent. 2013. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers،Vol. 2013, no. 2013, pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
Modern Language Association (MLA)
Şahın, Server…[et al.]. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers No. 2013 (2013), pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
American Medical Association (AMA)
Şahın, Server& Rüstemoğlu, Aydın& Tekcan, Akın& Tasliyurt, Turker& Güven, Hasan& Yığıt, Serbülent. Investigation of Associations between Obesity and LEP G2548A and LEPR 668AG Polymorphisms in a Turkish Population. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-677.
https://search.emarefa.net/detail/BIM-1031190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031190