CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma
المؤلفون المشاركون
Dosman, James A.
Senthilselvan, Ambikaipakan
Karunanayake, Chandima P.
Chen, Yue
Nakagawa, Kazuko
Pahwa, Punam
Rennie, Donna C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The CD14 gene has an important role in the detection of inflammatory provoking pathogens and in the ensuing signaling of the innate immune response.
We assessed the role of CD14 C-159T, G-1359T in the expression of asthma, croup, and allergy in Canadian school children of ages 6 to 14 years.
Methods.
Children attending schools in a rural community participated in a cross-sectional survey of respiratory health.
Following consent, we conducted clinical assessments to collect buccal swabs for genotyping and perform skin prick testing (SPT) to determine atopic status.
Genotyping and SPT results were available for 533 and 499 children, respectively.
Separate multivariable analyses that included both polymorphisms were conducted for each phenotype.
Results.
The prevalence of asthma, allergy, and croup was 18.6%, 22.4%, and 6.6%, respectively.
Children with the T/T variant of CD14 G-1359T were more likely to have physician diagnosed asthma (26.8%).
Children with C/C variant of CD14 C-159T had a significantly lower prevalence of croup (2.6%).
Haplotype analyses of the two CD14 polymorphisms showed that individuals with the T|T haplotype combination were significantly more likely to have asthma (P=0.014).
Conclusions.
In this study, CD14 variants are important for the expression of croup and asthma but not atopy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rennie, Donna C.& Karunanayake, Chandima P.& Chen, Yue& Nakagawa, Kazuko& Pahwa, Punam& Senthilselvan, Ambikaipakan…[et al.]. 2013. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rennie, Donna C.…[et al.]. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rennie, Donna C.& Karunanayake, Chandima P.& Chen, Yue& Nakagawa, Kazuko& Pahwa, Punam& Senthilselvan, Ambikaipakan…[et al.]. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031199
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر