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CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma
Joint Authors
Dosman, James A.
Senthilselvan, Ambikaipakan
Karunanayake, Chandima P.
Chen, Yue
Nakagawa, Kazuko
Pahwa, Punam
Rennie, Donna C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The CD14 gene has an important role in the detection of inflammatory provoking pathogens and in the ensuing signaling of the innate immune response.
We assessed the role of CD14 C-159T, G-1359T in the expression of asthma, croup, and allergy in Canadian school children of ages 6 to 14 years.
Methods.
Children attending schools in a rural community participated in a cross-sectional survey of respiratory health.
Following consent, we conducted clinical assessments to collect buccal swabs for genotyping and perform skin prick testing (SPT) to determine atopic status.
Genotyping and SPT results were available for 533 and 499 children, respectively.
Separate multivariable analyses that included both polymorphisms were conducted for each phenotype.
Results.
The prevalence of asthma, allergy, and croup was 18.6%, 22.4%, and 6.6%, respectively.
Children with the T/T variant of CD14 G-1359T were more likely to have physician diagnosed asthma (26.8%).
Children with C/C variant of CD14 C-159T had a significantly lower prevalence of croup (2.6%).
Haplotype analyses of the two CD14 polymorphisms showed that individuals with the T|T haplotype combination were significantly more likely to have asthma (P=0.014).
Conclusions.
In this study, CD14 variants are important for the expression of croup and asthma but not atopy.
American Psychological Association (APA)
Rennie, Donna C.& Karunanayake, Chandima P.& Chen, Yue& Nakagawa, Kazuko& Pahwa, Punam& Senthilselvan, Ambikaipakan…[et al.]. 2013. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
Modern Language Association (MLA)
Rennie, Donna C.…[et al.]. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
American Medical Association (AMA)
Rennie, Donna C.& Karunanayake, Chandima P.& Chen, Yue& Nakagawa, Kazuko& Pahwa, Punam& Senthilselvan, Ambikaipakan…[et al.]. CD14 Gene Variants and Their Importance for Childhood Croup, Atopy, and Asthma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031199