Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma
المؤلفون المشاركون
Patsouris, Efstratios
Giaginis, Costas
Efkarpidis, Themistoclis
Alexandrou, Paraskevi
Theocharis, Stamatios
Kouraklis, Gregory
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance.
The present study aimed to evaluate the clinical significance of the RCAS1 expression in gastric adenocarcinoma.
Material and Methods.
RCAS1 protein expression was assessed immunohistochemically on 54 gastric adenocarcinoma tissue samples and was analyzed in relation to clinicopathological parameters, tumor proliferative capacity, and patients’ survival.
Results.
Enhanced RCAS1 expression levels were significantly associated with advanced histopathological stage and presence of organ metastasis (P=0.0084 and P=0.0327).
Gastric cancer patients with elevated RCAS1 expression levels showed significantly shorter survival times compared to those with low RCAS1 expression (log-rank test, P=0.0168).
In multivariate analysis, histopathological stage and grade of differentiation as well as the RCAS1 expression were identified as independent prognostic factors (Cox regression analysis, P=0.0204, P=0.0035, and P=0.0081).
Conclusions.
Our data support the evidence that RCAS1 upregulation may contribute to gastric malignant progression, representing a useful biomarker to predict the biological behaviour and prognosis in gastric neoplasia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giaginis, Costas& Efkarpidis, Themistoclis& Alexandrou, Paraskevi& Patsouris, Efstratios& Kouraklis, Gregory& Theocharis, Stamatios. 2013. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giaginis, Costas…[et al.]. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giaginis, Costas& Efkarpidis, Themistoclis& Alexandrou, Paraskevi& Patsouris, Efstratios& Kouraklis, Gregory& Theocharis, Stamatios. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر