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Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma
Joint Authors
Patsouris, Efstratios
Giaginis, Costas
Efkarpidis, Themistoclis
Alexandrou, Paraskevi
Theocharis, Stamatios
Kouraklis, Gregory
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance.
The present study aimed to evaluate the clinical significance of the RCAS1 expression in gastric adenocarcinoma.
Material and Methods.
RCAS1 protein expression was assessed immunohistochemically on 54 gastric adenocarcinoma tissue samples and was analyzed in relation to clinicopathological parameters, tumor proliferative capacity, and patients’ survival.
Results.
Enhanced RCAS1 expression levels were significantly associated with advanced histopathological stage and presence of organ metastasis (P=0.0084 and P=0.0327).
Gastric cancer patients with elevated RCAS1 expression levels showed significantly shorter survival times compared to those with low RCAS1 expression (log-rank test, P=0.0168).
In multivariate analysis, histopathological stage and grade of differentiation as well as the RCAS1 expression were identified as independent prognostic factors (Cox regression analysis, P=0.0204, P=0.0035, and P=0.0081).
Conclusions.
Our data support the evidence that RCAS1 upregulation may contribute to gastric malignant progression, representing a useful biomarker to predict the biological behaviour and prognosis in gastric neoplasia.
American Psychological Association (APA)
Giaginis, Costas& Efkarpidis, Themistoclis& Alexandrou, Paraskevi& Patsouris, Efstratios& Kouraklis, Gregory& Theocharis, Stamatios. 2013. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
Modern Language Association (MLA)
Giaginis, Costas…[et al.]. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
American Medical Association (AMA)
Giaginis, Costas& Efkarpidis, Themistoclis& Alexandrou, Paraskevi& Patsouris, Efstratios& Kouraklis, Gregory& Theocharis, Stamatios. Increased RCAS1 Expression Is Associated with Advanced Histopathological Stage and Poor Prognosis in Patients with Gastric Adenocarcinoma. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031204