Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease
المؤلفون المشاركون
Fan, Daping
Wang, Hui
Zhou, Chiyan
Cao, Jia
Shang, Liang
Tong, Chuanfeng
Hu, Hanling
Yu, Hong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Paraoxonase-1 (PON1), a high-density-lipoprotein- (HDL-) associated enzyme, has the potential to protect against atherogenesis.
We examine the relationships between plasma PON1 activity and the progression of atherosclerosis as well as coronary artery disease (CAD).
Fasting blood samples were collected from female apolipoprotein E-deficient (apoE−/−) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement.
The severity of CAD was defined using angiographic Gensini score (GSS).
Compared to 3-month-old apoE−/− mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels.
In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group.
Interestingly, PON1 activity in severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS ≤ 40) (P<0.01).
There is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r=-0.393, P<0.001).
PON1 activity may be a potential biomarker for the severity of CAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Chiyan& Cao, Jia& Shang, Liang& Tong, Chuanfeng& Hu, Hanling& Wang, Hui…[et al.]. 2013. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Chiyan…[et al.]. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Chiyan& Cao, Jia& Shang, Liang& Tong, Chuanfeng& Hu, Hanling& Wang, Hui…[et al.]. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031227
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر