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Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease
Joint Authors
Fan, Daping
Wang, Hui
Zhou, Chiyan
Cao, Jia
Shang, Liang
Tong, Chuanfeng
Hu, Hanling
Yu, Hong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Paraoxonase-1 (PON1), a high-density-lipoprotein- (HDL-) associated enzyme, has the potential to protect against atherogenesis.
We examine the relationships between plasma PON1 activity and the progression of atherosclerosis as well as coronary artery disease (CAD).
Fasting blood samples were collected from female apolipoprotein E-deficient (apoE−/−) mice and 149 patients undergoing coronary angiography for the biochemical parameters measurement.
The severity of CAD was defined using angiographic Gensini score (GSS).
Compared to 3-month-old apoE−/− mice, aged mice had significantly lower PON1 activity, which is negatively correlated with the size of atherosclerotic lesion and plasma interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels.
In study patients, PON1 activity was correlated with age, sex, and HDL-cholesterol, apolipoprotein AI, and high-sensitivity C-reactive protein (hs-CRP) levels and was significantly lower in CAD group than that in non-CAD control group.
Interestingly, PON1 activity in severe CAD group (GSS > 40) was further significantly reduced compared to those in mild and moderate subgroups (GSS ≤ 40) (P<0.01).
There is a significant correlation between PON1 activity and the severity of CAD as assessed by GSS (r=-0.393, P<0.001).
PON1 activity may be a potential biomarker for the severity of CAD.
American Psychological Association (APA)
Zhou, Chiyan& Cao, Jia& Shang, Liang& Tong, Chuanfeng& Hu, Hanling& Wang, Hui…[et al.]. 2013. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
Modern Language Association (MLA)
Zhou, Chiyan…[et al.]. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
American Medical Association (AMA)
Zhou, Chiyan& Cao, Jia& Shang, Liang& Tong, Chuanfeng& Hu, Hanling& Wang, Hui…[et al.]. Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031227