![](/images/graphics-bg.png)
Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum
المؤلفون المشاركون
Robinson, Bruce W. S.
Creaney, Jenette
Sneddon, Sophie
Dick, Ian M.
Dare, Hanne
Musk, Arthur William
Skates, Steven J.
Boudville, Neil
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The MSLN gene products, soluble mesothelin and megakaryocyte potentiating factor (MPF), are being investigated as biomarkers for the asbestos-related cancer malignant mesothelioma (MM).
Pleural fluid biomarkers of MM can be elevated when serum levels remain normal.
The aim of this study was to determine if this was true for MPF and to compare levels of mesothelin.
Biomarker concentrations were compared in 66 MM patients, 39 patients with other malignancies, 37 with benign disease, 18 asbestos-exposed healthy individuals, and 53 patients with chronic kidney disease.
In pleural effusions, MPF and soluble mesothelin concentrations were both significantly elevated in MM patients relative to controls.
No significant difference between the area under the receiver operator curve (AUC) for MPF (0.945±0.02) and mesothelin (0.928±0.03) when distinguishing MM from all other causes of effusion was observed.
MPF and mesothelin serum concentrations were highly correlated and of equivalent diagnostic accuracy with AUCs of 0.813±0.04 and 0.829±0.03, respectively.
Serum levels of both markers increased with decreasing kidney function.
In conclusion, MPF is elevated in the pleural effusions of MM patients similar to that of mesothelin.
Mesothelin and MPF convey equivalent diagnostic information for distinguishing MM from other diseases in pleural effusions as well as serum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Creaney, Jenette& Sneddon, Sophie& Dick, Ian M.& Dare, Hanne& Boudville, Neil& Musk, Arthur William…[et al.]. 2013. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Creaney, Jenette…[et al.]. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Creaney, Jenette& Sneddon, Sophie& Dick, Ian M.& Dare, Hanne& Boudville, Neil& Musk, Arthur William…[et al.]. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)