Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum
Joint Authors
Robinson, Bruce W. S.
Creaney, Jenette
Sneddon, Sophie
Dick, Ian M.
Dare, Hanne
Musk, Arthur William
Skates, Steven J.
Boudville, Neil
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The MSLN gene products, soluble mesothelin and megakaryocyte potentiating factor (MPF), are being investigated as biomarkers for the asbestos-related cancer malignant mesothelioma (MM).
Pleural fluid biomarkers of MM can be elevated when serum levels remain normal.
The aim of this study was to determine if this was true for MPF and to compare levels of mesothelin.
Biomarker concentrations were compared in 66 MM patients, 39 patients with other malignancies, 37 with benign disease, 18 asbestos-exposed healthy individuals, and 53 patients with chronic kidney disease.
In pleural effusions, MPF and soluble mesothelin concentrations were both significantly elevated in MM patients relative to controls.
No significant difference between the area under the receiver operator curve (AUC) for MPF (0.945±0.02) and mesothelin (0.928±0.03) when distinguishing MM from all other causes of effusion was observed.
MPF and mesothelin serum concentrations were highly correlated and of equivalent diagnostic accuracy with AUCs of 0.813±0.04 and 0.829±0.03, respectively.
Serum levels of both markers increased with decreasing kidney function.
In conclusion, MPF is elevated in the pleural effusions of MM patients similar to that of mesothelin.
Mesothelin and MPF convey equivalent diagnostic information for distinguishing MM from other diseases in pleural effusions as well as serum.
American Psychological Association (APA)
Creaney, Jenette& Sneddon, Sophie& Dick, Ian M.& Dare, Hanne& Boudville, Neil& Musk, Arthur William…[et al.]. 2013. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
Modern Language Association (MLA)
Creaney, Jenette…[et al.]. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
American Medical Association (AMA)
Creaney, Jenette& Sneddon, Sophie& Dick, Ian M.& Dare, Hanne& Boudville, Neil& Musk, Arthur William…[et al.]. Comparison of the Diagnostic Accuracy of the MSLN Gene Products, Mesothelin and Megakaryocyte Potentiating Factor, as Biomarkers for Mesothelioma in Pleural Effusions and Serum. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1031233