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Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2
المؤلفون المشاركون
Ibara, Asako
Miyaji, Hirofumi
Nishida, Erika
Takita, Hiroko
Tanaka, Saori
Sugaya, Tsutomu
Kawanami, Masamitsu
Fugetsu, Bunshi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Nanoparticle bioceramics have become anticipated for biomedical applications.
Highly bioactive and biodegradable scaffolds would be developed using nanoparticles of β-tricalcium phosphate (β-TCP).
We prepared collagen scaffolds coated by nano-β-TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation.
The collagen sponge was coated with the nano-TCP dispersion and freeze-dried.
Scaffold was characterized by SEM, TEM, XRD, compressive testing and cell seeding.
Subsequently, the nano-β-TCP/collagen scaffold, collagen sponge, and each material loaded with FGF2 were implanted on rat cranial bone.
As a control, no implantation was performed.
Nano-TCP particles were found to be attached to the fibers of the collagen sponge by SEM and TEM observations.
Scaffold coated with nano-TCP showed higher compressive strength and cytocompatibility.
In histological evaluations at 10 days, inflammatory cells were rarely seen around the residual scaffold, suggesting that the nano-TCP material possesses good tissue compatibility.
At 35 days, bone augmentation and scaffold degradation in histological samples receiving nano-β-TCP scaffold were significantly greater than those in the control.
By loading of FGF2, advanced bone formation is facilitated, indicating that a combination with FGF2 would be effective for bone tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibara, Asako& Miyaji, Hirofumi& Fugetsu, Bunshi& Nishida, Erika& Takita, Hiroko& Tanaka, Saori…[et al.]. 2013. Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibara, Asako…[et al.]. Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2. Journal of Nanomaterials No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1031495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibara, Asako& Miyaji, Hirofumi& Fugetsu, Bunshi& Nishida, Erika& Takita, Hiroko& Tanaka, Saori…[et al.]. Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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