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Antimicrobial Activity of Hippurate Nanocomposite and Its Cytotoxicity Effect in Combination with Cytarabine against HL-60
المؤلفون المشاركون
Ismail, Maznah
Al-Qubaisi, Mothanna
Hussein, Mohd Zobir
El Zowalaty, Mohamed E.
Hussein-Al-Ali, Samer Hasan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hippuric acid (HA) was intercalated into a zinc-layered hydroxide (ZLH) by direct reaction of an aqueous suspension of zinc oxide with an aqueous solution of hippuric acid to obtain hippurate nanocomposite (HAN).
Various concentrations of hippuric acid (0.05, 0.2, and 0.4 molar) were used for the synthesis of the nanocomposite.
The as-synthesized HAN using 0.2 molar was found to give a well-ordered layered nanocomposite material with an increase in the basal spacing to 21.3 Å which indicated the insertion of hippurate organic moiety into the ZLH interlayers.
The cytotoxicity of HAN in combination with cytarabine against human promyelocytic leukemia cells (HL-60) was tested using MTT cell viability assay and trypan blue dye exclusion assay.
The combination of cytarabine with HAN showed higher tumor suppression efficiency as compared to that of cytarabine alone.
The IC50 values of HAN/cytarabine combination and cytarabine alone were 0.16±0.07 μg/mL and 0.17±0.09 μg/mL, respectively.
DNA fragmentation was also studied, and the exposure of HL-60 cells to cytarabine produced 10.70±0.96% DNA fragmentation compared to 18.90±1.33% when cells were exposed to combination of cytarabine with HAN.
The antimicrobial activity of hippuric acid and HAN nanocomposite was carried out against Gram-positive bacteria, Gram-negative bacteria, and yeasts.
It was found that Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus were more sensitive to HAN compared to Bacillus subtilis and Salmonella choleraesuis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hussein-Al-Ali, Samer Hasan& Al-Qubaisi, Mothanna& El Zowalaty, Mohamed E.& Hussein, Mohd Zobir& Ismail, Maznah. 2013. Antimicrobial Activity of Hippurate Nanocomposite and Its Cytotoxicity Effect in Combination with Cytarabine against HL-60. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hussein-Al-Ali, Samer Hasan…[et al.]. Antimicrobial Activity of Hippurate Nanocomposite and Its Cytotoxicity Effect in Combination with Cytarabine against HL-60. Journal of Nanomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hussein-Al-Ali, Samer Hasan& Al-Qubaisi, Mothanna& El Zowalaty, Mohamed E.& Hussein, Mohd Zobir& Ismail, Maznah. Antimicrobial Activity of Hippurate Nanocomposite and Its Cytotoxicity Effect in Combination with Cytarabine against HL-60. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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