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S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study
المؤلفون المشاركون
Perna, Giampaolo
Serroni, Nicola
De Berardis, Domenico
Di Iorio, Giuseppe
Valchera, Alessandro
Iasevoli, Felice
Signorelli, Maria
Salone, Anatolia
Rapini, Gabriella
Aguglia, Eugenio
Martinotti, Giovanni
di Giannantonio, Massimo
Marini, Stefano
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
We investigated the efficacy of S-Adenosyl-L-Methionine (SAMe) augmentation in patients with treatment-resistant depressive disorder (TRD).
Thirty-three outpatients with major depressive episode who failed to respond to at least 8 weeks of treatment with two adequate and stable doses of antidepressants were treated openly with fixed dose of SAMe (800 mg) for 8 weeks, added to existing medication.
The primary outcome measure was the change from baseline in total score on Hamilton Rating Scale for Depression (HAM-D).
The Clinical Global Impression of Improvement (CGI-I) was rated at the endpoint.
Patients with a reduction of 50% or more on HAM-D total score and a CGI-I score of 1 or 2 at endpoint were considered responders; remission was defined as a HAM-D score ≤7.
Secondary outcome measures included the Snaith-Hamilton Pleasure Scale (SHAPS) and the Sheehan Disability Scale (SDS).
At 8 weeks, a significant decrease in HAM-D score was observed with response achieved by 60% of the patients and remission by 36%.
Also a statistically significant reduction in SHAPS and SDS was observed.
Our findings indicate that SAMe augmentation may be effective and well tolerated in stage II TRD.
However, limitations of the present study must be considered and further placebo-controlled trials are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Berardis, Domenico& Marini, Stefano& Serroni, Nicola& Rapini, Gabriella& Iasevoli, Felice& Valchera, Alessandro…[et al.]. 2013. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Berardis, Domenico…[et al.]. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Berardis, Domenico& Marini, Stefano& Serroni, Nicola& Rapini, Gabriella& Iasevoli, Felice& Valchera, Alessandro…[et al.]. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1032650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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