S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study
Joint Authors
Perna, Giampaolo
Serroni, Nicola
De Berardis, Domenico
Di Iorio, Giuseppe
Valchera, Alessandro
Iasevoli, Felice
Signorelli, Maria
Salone, Anatolia
Rapini, Gabriella
Aguglia, Eugenio
Martinotti, Giovanni
di Giannantonio, Massimo
Marini, Stefano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We investigated the efficacy of S-Adenosyl-L-Methionine (SAMe) augmentation in patients with treatment-resistant depressive disorder (TRD).
Thirty-three outpatients with major depressive episode who failed to respond to at least 8 weeks of treatment with two adequate and stable doses of antidepressants were treated openly with fixed dose of SAMe (800 mg) for 8 weeks, added to existing medication.
The primary outcome measure was the change from baseline in total score on Hamilton Rating Scale for Depression (HAM-D).
The Clinical Global Impression of Improvement (CGI-I) was rated at the endpoint.
Patients with a reduction of 50% or more on HAM-D total score and a CGI-I score of 1 or 2 at endpoint were considered responders; remission was defined as a HAM-D score ≤7.
Secondary outcome measures included the Snaith-Hamilton Pleasure Scale (SHAPS) and the Sheehan Disability Scale (SDS).
At 8 weeks, a significant decrease in HAM-D score was observed with response achieved by 60% of the patients and remission by 36%.
Also a statistically significant reduction in SHAPS and SDS was observed.
Our findings indicate that SAMe augmentation may be effective and well tolerated in stage II TRD.
However, limitations of the present study must be considered and further placebo-controlled trials are needed.
American Psychological Association (APA)
De Berardis, Domenico& Marini, Stefano& Serroni, Nicola& Rapini, Gabriella& Iasevoli, Felice& Valchera, Alessandro…[et al.]. 2013. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
Modern Language Association (MLA)
De Berardis, Domenico…[et al.]. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
American Medical Association (AMA)
De Berardis, Domenico& Marini, Stefano& Serroni, Nicola& Rapini, Gabriella& Iasevoli, Felice& Valchera, Alessandro…[et al.]. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1032650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032650