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Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid
المؤلفون المشاركون
Pinto, Rui
Teixeira, Frederico
Sereno, José
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Palavra, Filipe
Freitas, Isabel
Isabel-Mendonça, Maria
Marado, Daniela
Reis, Flávio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles.
Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients.
The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1.
The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid.
Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions.
In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels.
This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mascarenhas-Melo, Filipa& Palavra, Filipe& Marado, Daniela& Sereno, José& Teixeira de Lemos, Edite& Freitas, Isabel…[et al.]. 2013. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mascarenhas-Melo, Filipa…[et al.]. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mascarenhas-Melo, Filipa& Palavra, Filipe& Marado, Daniela& Sereno, José& Teixeira de Lemos, Edite& Freitas, Isabel…[et al.]. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1032858
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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