Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid
Joint Authors
Pinto, Rui
Teixeira, Frederico
Sereno, José
Mascarenhas-Melo, Filipa
Teixeira de Lemos, Edite
Palavra, Filipe
Freitas, Isabel
Isabel-Mendonça, Maria
Marado, Daniela
Reis, Flávio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles.
Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients.
The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1.
The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid.
Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions.
In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels.
This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid.
American Psychological Association (APA)
Mascarenhas-Melo, Filipa& Palavra, Filipe& Marado, Daniela& Sereno, José& Teixeira de Lemos, Edite& Freitas, Isabel…[et al.]. 2013. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
Modern Language Association (MLA)
Mascarenhas-Melo, Filipa…[et al.]. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
American Medical Association (AMA)
Mascarenhas-Melo, Filipa& Palavra, Filipe& Marado, Daniela& Sereno, José& Teixeira de Lemos, Edite& Freitas, Isabel…[et al.]. Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c andor High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-1032858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1032858