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Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine
المؤلفون المشاركون
Hwang, Minwoo
Lee, Hee Jung
Song, Ho Joon
Kim, Byung Joo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Purpose.
Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate slow waves in the gastrointestinal (GI) tract.
We have aimed to investigate the effects of Socheongryong-Tang (SCRT) in ICCs from mouse’s small intestine.
Methods.
The whole-cell patch-clamp configuration was used to record membrane potentials from cultured ICCs.
Intracellular Ca2+ ([Ca2+]i) increase was studied in cultured ICCs using fura-2 AM.
Results.
ICCs generated pacemaker potentials in mouse’s small intestine.
SCRT produced membrane depolarization in current clamp mode.
Y25130 (5-HT3 receptor antagonist) and RS39604 (5-HT4 receptor antagonist) blocked SCRT-induced membrane depolarizations, whereas SB269970 (5-HT7 receptor antagonist) did not.
When GDP-β-S (1 mM) was in the pipette solution, SCRT did not induce the membrane depolarizations.
[Ca2+]i analysis showed that SCRT increased [Ca2+]i.
In the presence of PD98059 (p42/44 MAPK inhibitor), SCRT did not produce membrane depolarizations.
In addition, SB203580 (p38 MAPK inhibitor) and JNK inhibitors blocked the depolarizations by SCRT in pacemaker potentials.
Furthermore, the membrane depolarizations by SCRT were not inhibited by U-73122, an active phospholipase C (PLC) inhibitor, but by U-73343, an inactive PLC inhibitor.
Conclusion.
These results suggest that SCRT might affect GI motility by the modulation of pacemaker activity through MAPKs and PLC pathways in the ICCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hwang, Minwoo& Lee, Hee Jung& Song, Ho Joon& Kim, Byung Joo. 2013. Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1033038
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hwang, Minwoo…[et al.]. Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1033038
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hwang, Minwoo& Lee, Hee Jung& Song, Ho Joon& Kim, Byung Joo. Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1033038
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033038
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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