Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients
المؤلفون المشاركون
Salem, Ahmed M.
Ismail, Samira
Zarouk, Waheba A.
Abdul Baky, Olwya
Sayed, Ahmed A.
Abd El-Hamid, Sawsan
Salem, Sohair
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Autism is a neurodevelopmental disorder with indisputable evidence for a genetic component.
This work studied the association of autism with genetic variations in neurotransmitter-related genes, including MAOA uVNTR, MAOB rs1799836, and DRD2 TaqI A in 53 autistic patients and 30 healthy individuals.
The study also analyzed sequence variations of miR-431 and miR-21.
MAOA uVNTR was genotyped by PCR, MAOB and DRD2 polymorphisms were analyzed by PCR-based RFLP, and miR-431 and miR-21 were sequenced.
Low expressing allele of MAOA uVNTR was frequently higher in female patients compared to that in controls (OR = 2.25).
MAOB G allele frequency was more significantly increased in autistic patients than in controls (P<0.001 for both males and females).
DRD2 A1+ genotype increased autism risk (OR = 5.1).
Severity of autism tends to be slightly affected by MAOA/B genotype.
Plasma MAOB activity was significantly reduced in G than in A allele carrying males.
There was no significant difference in patients and maternal plasma MAOA/B activity compared to controls.
Neither mutations nor SNPs in miR-431 and miR-21 were found among studied patients.
This study threw light on some neurotransmitter-related genes suggesting their potential role in Autism pathogenesis that warrants further studies and much consideration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salem, Ahmed M.& Ismail, Samira& Zarouk, Waheba A.& Abdul Baky, Olwya& Sayed, Ahmed A.& Abd El-Hamid, Sawsan…[et al.]. 2013. Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salem, Ahmed M.…[et al.]. Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1033177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salem, Ahmed M.& Ismail, Samira& Zarouk, Waheba A.& Abdul Baky, Olwya& Sayed, Ahmed A.& Abd El-Hamid, Sawsan…[et al.]. Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1033177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1033177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر