Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells
المؤلفون المشاركون
Mohammadi-Motlagh, Hamid-Reza
Hosseinzadeh, Leila
Alipour, Maryam
Shokoohinia, Yalda
Mostafaie, Ali
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Natural products are excellent resources for finding lead structures for the development of chemotherapeutic agents.
Coumarins are a class of natural compounds found in a variety of plants.
In this study, we evaluated the cytotoxic potential of coumarins isolated from Prangos ferulacea (L.) Lindl.
in PC3, SKNMC, and H1299 (p53 null) human carcinoma cell lines.
Osthole proved to be an outstanding potent cytotoxic agent especially against PC3 cells.
Isoimperatorin exhibited moderate inhibitory effect against SKNMC and PC3 cell lines.
Oxypeucedanin and braylin did not display any cytotoxic activity.
In the next set of experiments, the apoptotic potentials of osthole and isoimperatorin were investigated.
Induction of apoptosis by isoimperatorin was accompanied by an increase in activation of caspase-3, -8, and -9 in SKNMC cells and caspase-3 and -9 in PC3 cells.
Moreover, isoimperatorin induced apoptosis by upregulating Bax and Smac/DIABLO genes in PC3 and SKNMC cells.
Osthole induced apoptosis by downregulating antiapoptotic Bcl-2 in only PC3 cells and upregulating the proapoptotic genes Bax and Smac/DIABLO in PC3, SKNMC, and H1299 cells.
The effects of osthole on H1299 cells are important because the loss of p53 has been associated with poor clinical prognosis in cancer treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Alipour, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. 2014. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shokoohinia, Yalda…[et al.]. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Alipour, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر