Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells
Joint Authors
Mohammadi-Motlagh, Hamid-Reza
Hosseinzadeh, Leila
Alipour, Maryam
Shokoohinia, Yalda
Mostafaie, Ali
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Natural products are excellent resources for finding lead structures for the development of chemotherapeutic agents.
Coumarins are a class of natural compounds found in a variety of plants.
In this study, we evaluated the cytotoxic potential of coumarins isolated from Prangos ferulacea (L.) Lindl.
in PC3, SKNMC, and H1299 (p53 null) human carcinoma cell lines.
Osthole proved to be an outstanding potent cytotoxic agent especially against PC3 cells.
Isoimperatorin exhibited moderate inhibitory effect against SKNMC and PC3 cell lines.
Oxypeucedanin and braylin did not display any cytotoxic activity.
In the next set of experiments, the apoptotic potentials of osthole and isoimperatorin were investigated.
Induction of apoptosis by isoimperatorin was accompanied by an increase in activation of caspase-3, -8, and -9 in SKNMC cells and caspase-3 and -9 in PC3 cells.
Moreover, isoimperatorin induced apoptosis by upregulating Bax and Smac/DIABLO genes in PC3 and SKNMC cells.
Osthole induced apoptosis by downregulating antiapoptotic Bcl-2 in only PC3 cells and upregulating the proapoptotic genes Bax and Smac/DIABLO in PC3, SKNMC, and H1299 cells.
The effects of osthole on H1299 cells are important because the loss of p53 has been associated with poor clinical prognosis in cancer treatment.
American Psychological Association (APA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Alipour, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. 2014. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
Modern Language Association (MLA)
Shokoohinia, Yalda…[et al.]. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
American Medical Association (AMA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Alipour, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells. Advances in Pharmacological and Pharmaceutical Sciences. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034361