Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset
المؤلفون المشاركون
da Silva, João Santana
Cunha, Fernando Queiroz
Sacramento, Laís Amorim
de Almeida, Roque Pacheco
Carregaro, Vanessa
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Visceral leishmaniasis (VL) is a chronic and fatal disease caused by Leishmania infantum in Brazil.
Leukocyte recruitment to infected tissue is a crucial event for the control of infections such as VL.
Leucotriens are lipid mediators synthesized by 5-lipoxygenase (5-LO) and they display a protective role against protozoan parasites by inducing several functions in leucocytes.
We determined the role of 5-LO activity in parasite control, focusing on the inflammatory immune response against Leishmania infantum infection.
LTB4 is released during in vitro infection.
The genetic ablation of 5-LO promoted susceptibility in highly resistant mice strains, harboring more parasites into target organs.
The susceptibility was related to the failure of neutrophil migration to the infectious foci.
Investigating the neutrophil failure, there was a reduction of proinflammatory cytokines involved in the related Th17 axis released into the organs.
Genetic ablation of 5-LO reduced the CD4+T cells producing IL-17, without interfering in Th1 subset.
L.
infantum failed to activate DC from 5 - LO - / - , showing reduced surface costimulatory molecule expression and proinflammatory cytokines involved in Th17 differentiation.
BLT1 blockage with selective antagonist interferes with DC maturation and proinflammatory cytokines release.
Thus, 5-LO activation coordinates the inflammatory immune response involved in the control of VL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sacramento, Laís Amorim& Cunha, Fernando Queiroz& de Almeida, Roque Pacheco& da Silva, João Santana& Carregaro, Vanessa. 2014. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sacramento, Laís Amorim…[et al.]. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sacramento, Laís Amorim& Cunha, Fernando Queiroz& de Almeida, Roque Pacheco& da Silva, João Santana& Carregaro, Vanessa. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034412
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر