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Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset
Joint Authors
da Silva, João Santana
Cunha, Fernando Queiroz
Sacramento, Laís Amorim
de Almeida, Roque Pacheco
Carregaro, Vanessa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Visceral leishmaniasis (VL) is a chronic and fatal disease caused by Leishmania infantum in Brazil.
Leukocyte recruitment to infected tissue is a crucial event for the control of infections such as VL.
Leucotriens are lipid mediators synthesized by 5-lipoxygenase (5-LO) and they display a protective role against protozoan parasites by inducing several functions in leucocytes.
We determined the role of 5-LO activity in parasite control, focusing on the inflammatory immune response against Leishmania infantum infection.
LTB4 is released during in vitro infection.
The genetic ablation of 5-LO promoted susceptibility in highly resistant mice strains, harboring more parasites into target organs.
The susceptibility was related to the failure of neutrophil migration to the infectious foci.
Investigating the neutrophil failure, there was a reduction of proinflammatory cytokines involved in the related Th17 axis released into the organs.
Genetic ablation of 5-LO reduced the CD4+T cells producing IL-17, without interfering in Th1 subset.
L.
infantum failed to activate DC from 5 - LO - / - , showing reduced surface costimulatory molecule expression and proinflammatory cytokines involved in Th17 differentiation.
BLT1 blockage with selective antagonist interferes with DC maturation and proinflammatory cytokines release.
Thus, 5-LO activation coordinates the inflammatory immune response involved in the control of VL.
American Psychological Association (APA)
Sacramento, Laís Amorim& Cunha, Fernando Queiroz& de Almeida, Roque Pacheco& da Silva, João Santana& Carregaro, Vanessa. 2014. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
Modern Language Association (MLA)
Sacramento, Laís Amorim…[et al.]. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
American Medical Association (AMA)
Sacramento, Laís Amorim& Cunha, Fernando Queiroz& de Almeida, Roque Pacheco& da Silva, João Santana& Carregaro, Vanessa. Protective Role of 5-Lipoxigenase during Leishmania infantum Infection Is Associated with Th17 Subset. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1034412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034412