Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer
المؤلفون المشاركون
Jiang, Yiguo
Huang, Jinkun
Wu, Jianjun
Li, Yuanqi
Li, Xun
Yang, Ti
Yang, Qiaoyuan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Lung cancer is the leading cause of cancer-related death and cigarette smoking is the main risk factor for lung cancer.
Circulating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer.
However, it is unclear whether changes in circulating miRNAs are associated with smoking and smoking-related lung cancer.
In this study, we determined the serum miRNA profiles of 10 nonsmokers, 10 smokers, and 10 lung-cancer patients with miRCURY LNA microRNA arrays.
The differentially expressed miRNAs were then confirmed in a larger sample.
We found that let-7i-3p and miR-154-5p were significantly downregulated in the sera of smokers and lung-cancer patients, so the serum levels of let-7i-3p and miR-154-5p are associated with smoking and smoking-related lung cancer.
The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively.
In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Jinkun& Wu, Jianjun& Li, Yuanqi& Li, Xun& Yang, Ti& Yang, Qiaoyuan…[et al.]. 2014. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Jinkun…[et al.]. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Jinkun& Wu, Jianjun& Li, Yuanqi& Li, Xun& Yang, Ti& Yang, Qiaoyuan…[et al.]. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034444
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر