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Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer
Joint Authors
Jiang, Yiguo
Huang, Jinkun
Wu, Jianjun
Li, Yuanqi
Li, Xun
Yang, Ti
Yang, Qiaoyuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer-related death and cigarette smoking is the main risk factor for lung cancer.
Circulating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer.
However, it is unclear whether changes in circulating miRNAs are associated with smoking and smoking-related lung cancer.
In this study, we determined the serum miRNA profiles of 10 nonsmokers, 10 smokers, and 10 lung-cancer patients with miRCURY LNA microRNA arrays.
The differentially expressed miRNAs were then confirmed in a larger sample.
We found that let-7i-3p and miR-154-5p were significantly downregulated in the sera of smokers and lung-cancer patients, so the serum levels of let-7i-3p and miR-154-5p are associated with smoking and smoking-related lung cancer.
The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively.
In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.
American Psychological Association (APA)
Huang, Jinkun& Wu, Jianjun& Li, Yuanqi& Li, Xun& Yang, Ti& Yang, Qiaoyuan…[et al.]. 2014. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
Modern Language Association (MLA)
Huang, Jinkun…[et al.]. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
American Medical Association (AMA)
Huang, Jinkun& Wu, Jianjun& Li, Yuanqi& Li, Xun& Yang, Ti& Yang, Qiaoyuan…[et al.]. Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1034444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034444