Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit
المؤلفون المشاركون
Yilmaz, Mesut
Mataraci-Kara, Emel
Ozbek-Celik, Berna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Colistin, tigecycline, levofloxacin, tobramycin, and rifampin alone and in combination with doripenem were investigated for their in vitro activities and postantibiotic effects (PAEs) on Klebsiella pneumoniae.
The in vitro activities of tested antibiotics in combination with doripenem were determined using a microbroth checkerboard technique.
To determine the PAEs, K.
pneumoniae strains in the logarithmic phase of growth were exposed for 1 h to antibiotics, alone and in combination.
Recovery periods of test cultures were evaluated using viable counting after centrifugation.
Colistin, tobramycin, and levofloxacin produced strong PAEs ranging from 2.71 to 4.23 h, from 1.31 to 3.82 h, and from 1.35 to 4.72, respectively, in a concentration-dependent manner.
Tigecycline and rifampin displayed modest PAEs ranging from 1.18 h to 1.55 h and 0.92 to 1.19, respectively.
Because it is a beta-lactam, PAEs were not exactly induced by doripenem (ranging from 0.10 to 0.18 h).
In combination, doripenem scarcely changed the duration of PAE of each tested antibiotic alone.
The findings of this study may have important implications for the timing of doses during K.
pneumoniae therapy with tested antibiotics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ozbek-Celik, Berna& Mataraci-Kara, Emel& Yilmaz, Mesut. 2014. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ozbek-Celik, Berna…[et al.]. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ozbek-Celik, Berna& Mataraci-Kara, Emel& Yilmaz, Mesut. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر