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Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit
Joint Authors
Yilmaz, Mesut
Mataraci-Kara, Emel
Ozbek-Celik, Berna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Colistin, tigecycline, levofloxacin, tobramycin, and rifampin alone and in combination with doripenem were investigated for their in vitro activities and postantibiotic effects (PAEs) on Klebsiella pneumoniae.
The in vitro activities of tested antibiotics in combination with doripenem were determined using a microbroth checkerboard technique.
To determine the PAEs, K.
pneumoniae strains in the logarithmic phase of growth were exposed for 1 h to antibiotics, alone and in combination.
Recovery periods of test cultures were evaluated using viable counting after centrifugation.
Colistin, tobramycin, and levofloxacin produced strong PAEs ranging from 2.71 to 4.23 h, from 1.31 to 3.82 h, and from 1.35 to 4.72, respectively, in a concentration-dependent manner.
Tigecycline and rifampin displayed modest PAEs ranging from 1.18 h to 1.55 h and 0.92 to 1.19, respectively.
Because it is a beta-lactam, PAEs were not exactly induced by doripenem (ranging from 0.10 to 0.18 h).
In combination, doripenem scarcely changed the duration of PAE of each tested antibiotic alone.
The findings of this study may have important implications for the timing of doses during K.
pneumoniae therapy with tested antibiotics.
American Psychological Association (APA)
Ozbek-Celik, Berna& Mataraci-Kara, Emel& Yilmaz, Mesut. 2014. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
Modern Language Association (MLA)
Ozbek-Celik, Berna…[et al.]. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
American Medical Association (AMA)
Ozbek-Celik, Berna& Mataraci-Kara, Emel& Yilmaz, Mesut. Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1034450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034450