Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats
المؤلفون المشاركون
Zheng, Li Wu
Liu, Xi Ling
Lu, Weijia William
Zwahlen, Roger A.
Li, Chun Lei
Cai, Wei Xin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Technically primates and dogs represent ideal models to investigate diseases characterized by abnormal intracortical remodeling.
High expenses and ethical issues, however, restrict the use of those animals in research.
Rodent models have been used as alternatives instead, but their value is limited, if none, because these animals lack intracortical bone remodeling.
This study aimed at investigating the effect of ovariectomy onto the stimulation of intracortical remodeling in rat mandibles.
Materials and Methods.
Sixteen 12-week-old Spraque-Dawly (SD) female rats were randomly assigned into two groups, receiving either ovariectomy or sham operation.
All the rats were sacrificed 18 weeks postoperatively.
The entire mandibles were harvested for microcomputed tomography (micro-CT) and histomorphometric assessments.
Results.
Micro-CT examination showed significantly decreased bone mineral density (0.95 ± 0.01 versus 1.01 ± 0.02 g/cm3, P < 0.0 0 1 ) and bone volume (65.78 ± 5.45 versus 87.41 ± 4.12%, P < 0.0 0 1 ) in ovariectomy group.
Histomorphometric assessment detected a sixfold increased intracortical bone remodeling as well as an increased bone modeling in mandibles of ovariectomized rats.
Conclusion.
For the first time, to the authors’ knowledge, it was detected that ovariectomy stimulates intracortical remodeling in rat mandibles.
This animal model might be of use to study various bone diseases associated with an abnormal intracortical remodeling process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chun Lei& Liu, Xi Ling& Cai, Wei Xin& Lu, Weijia William& Zwahlen, Roger A.& Zheng, Li Wu. 2014. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chun Lei…[et al.]. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chun Lei& Liu, Xi Ling& Cai, Wei Xin& Lu, Weijia William& Zwahlen, Roger A.& Zheng, Li Wu. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر