![](/images/graphics-bg.png)
Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats
Joint Authors
Zheng, Li Wu
Liu, Xi Ling
Lu, Weijia William
Zwahlen, Roger A.
Li, Chun Lei
Cai, Wei Xin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Technically primates and dogs represent ideal models to investigate diseases characterized by abnormal intracortical remodeling.
High expenses and ethical issues, however, restrict the use of those animals in research.
Rodent models have been used as alternatives instead, but their value is limited, if none, because these animals lack intracortical bone remodeling.
This study aimed at investigating the effect of ovariectomy onto the stimulation of intracortical remodeling in rat mandibles.
Materials and Methods.
Sixteen 12-week-old Spraque-Dawly (SD) female rats were randomly assigned into two groups, receiving either ovariectomy or sham operation.
All the rats were sacrificed 18 weeks postoperatively.
The entire mandibles were harvested for microcomputed tomography (micro-CT) and histomorphometric assessments.
Results.
Micro-CT examination showed significantly decreased bone mineral density (0.95 ± 0.01 versus 1.01 ± 0.02 g/cm3, P < 0.0 0 1 ) and bone volume (65.78 ± 5.45 versus 87.41 ± 4.12%, P < 0.0 0 1 ) in ovariectomy group.
Histomorphometric assessment detected a sixfold increased intracortical bone remodeling as well as an increased bone modeling in mandibles of ovariectomized rats.
Conclusion.
For the first time, to the authors’ knowledge, it was detected that ovariectomy stimulates intracortical remodeling in rat mandibles.
This animal model might be of use to study various bone diseases associated with an abnormal intracortical remodeling process.
American Psychological Association (APA)
Li, Chun Lei& Liu, Xi Ling& Cai, Wei Xin& Lu, Weijia William& Zwahlen, Roger A.& Zheng, Li Wu. 2014. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
Modern Language Association (MLA)
Li, Chun Lei…[et al.]. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
American Medical Association (AMA)
Li, Chun Lei& Liu, Xi Ling& Cai, Wei Xin& Lu, Weijia William& Zwahlen, Roger A.& Zheng, Li Wu. Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1034461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034461