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Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALBc Mice Model
المؤلفون المشاركون
How, Chee Wun
Rahman, Heshu Sulaiman
Abdul Samad, Nozlena
Ng, Kuan Beng
Anasamy, Theebaa
Chartrand, Max Stanley
Othman, Hemn Hassan
Namvar, Farideh
Andas, A. Reenaa Joys
Muhammad Nadzri, Nabilah
Rasedee, Abdullah
Yeap, Swee Keong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Zerumbone- (ZER-) loaded nanostructure lipid carrier (NLC) (ZER-NLC) prepared for its antileukemia effect in vitro was evaluated for its toxicological effects by observing changes in the liver, kidney, spleen, lung, heart, and brain tissues, serum biochemical parameters, total haemogram, and bone marrow stem cells.
The acute toxicity study for ZER-NLC was conducted by orally treating BALB/c mice with a single dose with either water, olive oil, ZER, NLC, or ZER-NLC for 14 days.
The animals were observed for clinical and behavioral abnormalities, toxicological symptoms, feed consumption, and gross appearance.
The liver, kidney, heart, lung, spleen, and brain tissues were assessed histologically.
Total haemogram was counted by hemocytometry and microhematocrit reader.
Bone marrow examination in terms of cellular morphology was done by Wright staining with bone marrow smear.
Furthermore, serum biochemical parameters were determined spectrophotometrically.
Grossly all treated mice, their investigated tissues, serum biochemical parameters, total haemogram, and bone marrow were normal.
At oral doses of 100 and 200 mg/kg ZER-NLC there was no sign of toxicity or mortality in BALB/c mice.
This study suggests that the 50% lethal dose (LD50) of ZER-NLC is higher than 200 mg/kg, thus, safe by oral administration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahman, Heshu Sulaiman& Rasedee, Abdullah& Othman, Hemn Hassan& Chartrand, Max Stanley& Namvar, Farideh& Yeap, Swee Keong…[et al.]. 2014. Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALBc Mice Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahman, Heshu Sulaiman…[et al.]. Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALBc Mice Model. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1034499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahman, Heshu Sulaiman& Rasedee, Abdullah& Othman, Hemn Hassan& Chartrand, Max Stanley& Namvar, Farideh& Yeap, Swee Keong…[et al.]. Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALBc Mice Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1034499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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