Viola tricolor Induces Apoptosis in Cancer Cells and Exhibits Antiangiogenic Activity on Chicken Chorioallantoic Membrane
المؤلفون المشاركون
Tayarani-Najaran, Zahra
Sadeghnia, Hamid Reza
Ghorbani Hesari, Taghi
Mousavi, Seyed Hadi
Ghorbani, Ahmad
Mortazavian, Seyed Mohsen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In the present study, the cytotoxic and apoptogenic properties of hydroalcoholic extract and ethyl acetate (EtOAc), n-butanol, and water fractions (0–800 μg/mL) of Viola tricolor were investigated in Neuro2a mouse neuroblastoma and MCF-7 human breast cancer cells.
In addition, antiangiogenic effect of EtOAc fraction was evaluated on chicken chorioallantoic membrane (CAM).
The quality of EtOAc fraction was also characterized using high performance liquid chromatography (HPLC) fingerprint.
Cytotoxicity assay revealed that EtOAc fraction was the most potent among all fractions with maximal effect on MCF-7 and minimal toxicity against normal murine fibroblast L929 cells.
Apoptosis induction by EtOAc fraction was confirmed by increased sub-G1 peak of propidium iodide (PI) stained cells.
This fraction triggered the apoptotic pathway by increased Bax/Bcl-2 ratio and cleaved caspase-3 level.
Moreover, treatment with EtOAc fraction significantly decreased the diameter of vessels on CAM, while the number of newly formed blood vessels was not suppressed significantly.
Analysis of quality of EtOAc fraction using HPLC fingerprint showed six major peaks with different retention times.
The results of the present study suggest that V.
tricolor has potential anticancer property by inducing apoptosis and inhibiting angiogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadeghnia, Hamid Reza& Ghorbani Hesari, Taghi& Mortazavian, Seyed Mohsen& Mousavi, Seyed Hadi& Tayarani-Najaran, Zahra& Ghorbani, Ahmad. 2014. Viola tricolor Induces Apoptosis in Cancer Cells and Exhibits Antiangiogenic Activity on Chicken Chorioallantoic Membrane. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadeghnia, Hamid Reza…[et al.]. Viola tricolor Induces Apoptosis in Cancer Cells and Exhibits Antiangiogenic Activity on Chicken Chorioallantoic Membrane. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1034514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadeghnia, Hamid Reza& Ghorbani Hesari, Taghi& Mortazavian, Seyed Mohsen& Mousavi, Seyed Hadi& Tayarani-Najaran, Zahra& Ghorbani, Ahmad. Viola tricolor Induces Apoptosis in Cancer Cells and Exhibits Antiangiogenic Activity on Chicken Chorioallantoic Membrane. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1034514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر