Changes in ADMADDAH Pathway after Hepatic IschemiaReperfusion Injury in Rats: The Role of Bile
المؤلفون المشاركون
Ferrigno, Andrea
Berardo, Clarissa
Bianchi, Alberto
Rizzo, Vittoria
Richelmi, Plinio
Vairetti, Mariapia
Di Pasqua, Laura G.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the effects of hepatic ischemia/reperfusion (I/R) injury on asymmetric dimethylarginine (ADMA, a nitric oxide synthase inhibitor), protein methyltransferase (PRMT) and dimethylarginine dimethylaminohydrolase (DDAH) (involved, resp., in ADMA synthesis and degradation), and the cationic transporter (CAT).
Male Wistar rats were subjected to 30 or 60 min hepatic ischemia followed by 60 min reperfusion.
ADMA levels in serum and bile were determined.
Tissue ADMA, DDAH activity, DDAH-1 and CAT-2 protein, DDAH-1 and PRMT-1 mRNA expression, GSH/GSSG, ROS production, and lipid peroxidation were detected.
ADMA was found in bile.
I/R increased serum and bile ADMA levels while an intracellular decrease was detected after 60 min ischemia.
Decreased DDAH activity, mRNA, and protein expression were observed at the end of reperfusion.
No significant difference was observed in GSH/GSSG, ROS, lipid peroxidation, and CAT-2; a decrease in PRMT-1 mRNA expression was found after I/R.
Liver is responsible for the biliary excretion of ADMA, as documented here for the first time, and I/R injury is associated with an oxidative stress-independent alteration in DDAH activity.
These data are a step forward in the understanding of the pathways that regulate serum, tissue, and biliary levels of ADMA in which DDAH enzyme plays a crucial role.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferrigno, Andrea& Rizzo, Vittoria& Bianchi, Alberto& Di Pasqua, Laura G.& Berardo, Clarissa& Richelmi, Plinio…[et al.]. 2014. Changes in ADMADDAH Pathway after Hepatic IschemiaReperfusion Injury in Rats: The Role of Bile. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferrigno, Andrea…[et al.]. Changes in ADMADDAH Pathway after Hepatic IschemiaReperfusion Injury in Rats: The Role of Bile. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1034515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferrigno, Andrea& Rizzo, Vittoria& Bianchi, Alberto& Di Pasqua, Laura G.& Berardo, Clarissa& Richelmi, Plinio…[et al.]. Changes in ADMADDAH Pathway after Hepatic IschemiaReperfusion Injury in Rats: The Role of Bile. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1034515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر