![](/images/graphics-bg.png)
Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos
المؤلفون المشاركون
Meraz-Ríos, Marco Antonio
Santana, Carla
Noris, Gino
Camacho-Mejorado, Rafael
Acosta-Saavedra, Leonor C.
Calderón-Aranda, Emma S.
Hernández-Juárez, Jesús
Magaña, Jonathan J.
Gómez, Rocío
Majluf-Cruz, Abraham
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality.
Genetic factors play a critical role in its aetiology.
Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms.
Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers.
Methods.
Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods.
The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations.
Results.
The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE.
Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.02–3.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93–21.49).
Conclusions.
The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins.
Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meraz-Ríos, Marco Antonio& Majluf-Cruz, Abraham& Santana, Carla& Noris, Gino& Camacho-Mejorado, Rafael& Acosta-Saavedra, Leonor C.…[et al.]. 2014. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meraz-Ríos, Marco Antonio…[et al.]. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meraz-Ríos, Marco Antonio& Majluf-Cruz, Abraham& Santana, Carla& Noris, Gino& Camacho-Mejorado, Rafael& Acosta-Saavedra, Leonor C.…[et al.]. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034543
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)