Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos
Joint Authors
Meraz-Ríos, Marco Antonio
Santana, Carla
Noris, Gino
Camacho-Mejorado, Rafael
Acosta-Saavedra, Leonor C.
Calderón-Aranda, Emma S.
Hernández-Juárez, Jesús
Magaña, Jonathan J.
Gómez, Rocío
Majluf-Cruz, Abraham
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality.
Genetic factors play a critical role in its aetiology.
Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms.
Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers.
Methods.
Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods.
The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations.
Results.
The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE.
Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.02–3.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93–21.49).
Conclusions.
The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins.
Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.
American Psychological Association (APA)
Meraz-Ríos, Marco Antonio& Majluf-Cruz, Abraham& Santana, Carla& Noris, Gino& Camacho-Mejorado, Rafael& Acosta-Saavedra, Leonor C.…[et al.]. 2014. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
Modern Language Association (MLA)
Meraz-Ríos, Marco Antonio…[et al.]. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
American Medical Association (AMA)
Meraz-Ríos, Marco Antonio& Majluf-Cruz, Abraham& Santana, Carla& Noris, Gino& Camacho-Mejorado, Rafael& Acosta-Saavedra, Leonor C.…[et al.]. Association of vWA and TPOX Polymorphisms with Venous Thrombosis in Mexican Mestizos. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034543