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Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
المؤلفون المشاركون
Lee, Kuei-Fang
Chen, Yi-Cheng
Hsu, Paul Wei-Che
Wu, Lawrence Shih-Hsin
Chi, Yu-Hsiang
Chen, Ching-Kai
Liu, Ingrid Y.
Weng, Julia Tzu-Ya
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood.
In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear.
In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted.
Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling.
Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure.
Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage.
In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations.
Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Kuei-Fang& Weng, Julia Tzu-Ya& Hsu, Paul Wei-Che& Chi, Yu-Hsiang& Chen, Ching-Kai& Liu, Ingrid Y.…[et al.]. 2014. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Kuei-Fang…[et al.]. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Kuei-Fang& Weng, Julia Tzu-Ya& Hsu, Paul Wei-Che& Chi, Yu-Hsiang& Chen, Ching-Kai& Liu, Ingrid Y.…[et al.]. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1034579
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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