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Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
Joint Authors
Lee, Kuei-Fang
Chen, Yi-Cheng
Hsu, Paul Wei-Che
Wu, Lawrence Shih-Hsin
Chi, Yu-Hsiang
Chen, Ching-Kai
Liu, Ingrid Y.
Weng, Julia Tzu-Ya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood.
In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear.
In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted.
Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling.
Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure.
Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage.
In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations.
Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
American Psychological Association (APA)
Lee, Kuei-Fang& Weng, Julia Tzu-Ya& Hsu, Paul Wei-Che& Chi, Yu-Hsiang& Chen, Ching-Kai& Liu, Ingrid Y.…[et al.]. 2014. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
Modern Language Association (MLA)
Lee, Kuei-Fang…[et al.]. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
American Medical Association (AMA)
Lee, Kuei-Fang& Weng, Julia Tzu-Ya& Hsu, Paul Wei-Che& Chi, Yu-Hsiang& Chen, Ching-Kai& Liu, Ingrid Y.…[et al.]. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1034579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1034579