Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer

الملخص EN

Purpose.

To investigate promoter methylation in the deleted in lung and esophageal cancer 1 (DLEC1) gene in Chinese patients with gastric cancer.

Methods.

A total of 227 patients with gastric cancer were enrolled.

The methylations of the promoter regions of DLEC1 and ACTB were determined using quantitative methylation-specific PCR.

The DLEC1 methylation was compared to the clinicopathological variables of gastric cancer.

Results.

DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer.

Patients with DLEC1-hypermethylated gastric cancer had significantly higher recurrence rate than those with DLEC1-hypomethylated gastric cancer ( P = 0.025 ; hazard ratio = 2.43 ).

Conclusions.

Methylation of DELC1 promoter may be a valuable predictor for recurrence in Chinese patients with gastric cancer.