Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer
Joint Authors
Feng, Gang
Ye, Xiaobing
Jiao, Nanlin
Pu, Chun
Zhao, Guohai
Sun, Guoping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate promoter methylation in the deleted in lung and esophageal cancer 1 (DLEC1) gene in Chinese patients with gastric cancer.
Methods.
A total of 227 patients with gastric cancer were enrolled.
The methylations of the promoter regions of DLEC1 and ACTB were determined using quantitative methylation-specific PCR.
The DLEC1 methylation was compared to the clinicopathological variables of gastric cancer.
Results.
DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer.
Patients with DLEC1-hypermethylated gastric cancer had significantly higher recurrence rate than those with DLEC1-hypomethylated gastric cancer ( P = 0.025 ; hazard ratio = 2.43 ).
Conclusions.
Methylation of DELC1 promoter may be a valuable predictor for recurrence in Chinese patients with gastric cancer.
American Psychological Association (APA)
Ye, Xiaobing& Feng, Gang& Jiao, Nanlin& Pu, Chun& Zhao, Guohai& Sun, Guoping. 2014. Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035059
Modern Language Association (MLA)
Ye, Xiaobing…[et al.]. Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035059
American Medical Association (AMA)
Ye, Xiaobing& Feng, Gang& Jiao, Nanlin& Pu, Chun& Zhao, Guohai& Sun, Guoping. Methylation of DLEC1 Promoter Is a Predictor for Recurrence in Chinese Patients with Gastric Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035059
